Sperm Motility

Supervisors: Klaus Reinhardt

Background: Sperm motility is a key parameter of male fertility in both animals and humans. We know that sperm parameters change with many parameters such as diet and nutrition, male age or mitochondrial haplotype but also with the medium the sperm is kept in. Be the first in the world to investigate sperm motility in insects in your thesis. More interesting (i.e., relevant for a MSc project) is the question how sperm motility can evolve through males if it is driven by sperm mitochondria but mitochondria are only inherited through females. And it is not clear how well the mitochondria work in different nuclear background. Interested? Get in touch.

References:

Moraes CR, Meyers S. 2018. The sperm mitochondrion: Organelle of many functions. Animal Reproduction Science 194: 71-80 Link

Ruiz-Pesini E, Diez-Sanchez C, Lopez-Perez, Enriquez JA. 2007. The Role of the Mitochondrion in Sperm Function: Is There a Place for Oxidative Phosphorylation or Is This a Purely Glycolytic Process? Curr Topics Dev Biol 77: 3-19.

Turnell BR, Reinhardt K. 2020. Metabolic rate and oxygen radical levels increase but radical generation rate decreases with male age in Drosophila melanogaster sperm. Journal of Gerontology A 75: 2278–2285 link. or pdf file here.

Wetzker C, Reinhardt K. 2019. Distinct metabolic profiles in Drosophila sperm and somatic tissues revealed by two-photon NAD(P)H and FAD autofluorescence lifetime imaging. Scientific Reports 9:19534. Link