Mitochondria and Sperm Motility

Supervisors: Klaus Reinhardt

Background: (Insect) sperm cells contain mitochondria but their role in energy metabolism is not clear, nor is it clear how well the mitochondria work in different nuclear background. Mitochondria also play a role in ageing and, reversely, ageing affects mitochondrial function. This project will analyse sperm motility of males of different ages of our mitolines, where we are able to separate the effects of the mitochondrial and the nuclear genome. Interested? Get in touch.

References:

Moraes CR, Meyers S. 2018. The sperm mitochondrion: Organelle of many functions. Animal Reproduction Science 194: 71-80 Link

Ruiz-Pesini E, Diez-Sanchez C, Lopez-Perez, Enriquez JA. 2007. The Role of the Mitochondrion in Sperm Function: Is There a Place for Oxidative Phosphorylation or Is This a Purely Glycolytic Process? Curr Topics Dev Biol 77: 3-19.

Wetzker C, Reinhardt K. 2019. Distinct metabolic profiles in Drosophila sperm and somatic tissues revealed by two-photon NAD(P)H and FAD autofluorescence lifetime imaging. Scientific Reports 9:19534. Link